FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRα1EMS1
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General Information
Symbol
Dmel\nAChRα1EMS1
Species
D. melanogaster
Name
FlyBase ID
FBal0246779
Feature type
allele
Associated gene
Dmel\nAChRα1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Perry et al., 2008)
Progenitor genotype
Cytology
Description

11bp deletion of nucleotides 2807-2817 (coordinates relative to GenBank accession NM_079757). This results in a frameshift which is expected to result in the loss of M4, the last transmembrane domain, and to extend the predicted protein by an additional 72 missense amino acids.

(Perry et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,401,878..24,401,888 [-]
Comment:

Deletion of 11 bp (bases 2807-2817 GB:NM_079757)

(Perry et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show increased resistance to nitenpyram compared to wild-type controls. This resistance is incompletely recessive.

      (Perry et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      nAChRα1EMS1, nAChRβ2EMS2 has viable phenotype

      (Perry et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Dα1EMS1
      (Chen et al., 2022)
      EMS1
      (Perry et al., 2008)
      Ems1
      (Perry et al., 2008)
      nAChRα1EMS1
      nAcRα-96AaEMS1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)