FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRβ2EMS4
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General Information
Symbol
Dmel\nAChRβ2EMS4
Species
D. melanogaster
Name
FlyBase ID
FBal0246782
Feature type
allele
Associated gene
Dmel\nAChRβ2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Perry et al., 2008)
Progenitor genotype
Cytology
Description

Nucleotides 484-485 (TG, coordinates relative to GenBank accession NM_079759) are replaced with CCGGCACA. This results in the Leu residue at position 118 within Loop A being replaced with Ser, Gly and Thr.

(Perry et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:24,514,337..24,514,338 [-]
Inserted_sequence:

CCGGCACA

Comment:

TG at coordinates 484-485 of NM_079759 is replaced with CCGGCACA, resulting in the Leu residue at position 118 being replaced with Ser, Gly, Thr.

(Perry et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show increased resistance to nitenpyram compared to wild-type controls. This resistance is incompletely recessive.

      (Perry et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EMS4
      (Perry et al., 2008)
      Ems4
      (Perry et al., 2008)
      nAChRβ2EMS4
      nAcRβ-96AEMS4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)