FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\DaxxU26
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General Information
Symbol
Dmel\DaxxU26
Species
D. melanogaster
Name
FlyBase ID
FBal0246798
Feature type
allele
Associated gene
Dmel\Daxx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Bodai et al., 2007)
Progenitor genotype
Cytology
Description

Imprecise excision of an insertion in the first intron of DLP, resulting in a 1.7kb deletion that removes the downstream part of the first intron and 1296bp of coding sequence from the second exon.

(Bodai et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:6,481,594..6,483,278 [+]
Comment:

Approximate boundaries of 1.7 kb deletion resulting from the imprecise excision of P{RS3}DaxxCB-6241-3 (curator deduction from description - one of two insertions in the first intron of Daxx used for creating excisions). The deletion takes out part of the intron and 1296 bp of exon 2.

(Bodai et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant third instar larvae show no reduction in survival after irradiation with 2krad X rays compared to control larvae. Homozygotes show a decreased rate of loss of heterozygosity (LOH) after irradiation compared to control flies. The average number of eggs laid by DaxxU32/DaxxU26 females in a 24 hour interval is significantly less than the number laid by control females. The median of the lifespan of homozygous males is significantly decreased compared to that of control males.

      Mutant third instar larvae show no reduction in survival after irradiation with 2krad X rays compared to control larvae. The average number of eggs laid by DaxxU32/DaxxU26 females in a 24 hour interval is significantly less than the number laid by control females. The median of the lifespan of homozygous males is significantly decreased compared to that of control males.

      (Bodai et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Two-thirds of animals expressing p53Scer\UAS.cJa under the control of Scer\GAL4Act5C.PI in a DLPU26/DLPU26 background die in early pupal stage and only 9% of them eclose.

      (Bodai et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DLPU26
      (Bodai et al., 2007)
      DaxxU26
      Name Synonyms
      Secondary FlyBase IDs
        References (1)