FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lsd-12
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General Information
Symbol
Dmel\Lsd-12
Species
D. melanogaster
Name
FlyBase ID
FBal0247948
Feature type
allele
Associated gene
Dmel\Lsd-1
Associated Insertion(s)
P{?EP}Lsd-12
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Beller et al., 2010, Beller et al., 2010)
Progenitor genotype
P{EP}Lsd-1G4304
(Beller et al., 2010, Beller et al., 2010)
Associated Insertion(s)
P{?EP}Lsd-12
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in partial deletion of nucleotides -509 to +399 relative to the putative Lsd-1 start site (this deletes sequences encoding amino acid residues 1-133). 709bp of the original inserted element remains.

(Beller et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:23,763,804..23,764,844 [+]
Comment:

Estimated boundaries of a deletion resulting from the imprecise excsion of P{EP}Lsd-1G4304, which removes sequences from -509 relative to the Lsd-1 translation start site up through amino acid 133. 709 bb of residual P element sequences remain

(Beller et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA with Lsd-11
      (Beller et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes develop into obese but otherwise normal-looking adults.

      Lsd-11/Lsd-12 flies have double the fat content of control flies.

      Lsd-11/Lsd-12 flies show increased resistance to starvation compared to control flies.

      (Beller et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lsd-12
      plin2
      (Beller et al., 2010, Beller et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)