Flies expressing RhoBTB^HMS00411 (combined with UAS-Dicer2 to enhance RNAi efficacy) under the control of Scer\GAL4^elav.PU display a weak bang sensitive phenotype (and remain paralyzed or with spasms for a prolonged period of time after vortexing, whereas control flies recover immediately or within a few seconds) as well as a rather weak climbing deficiency, no defects in the climbing ability are observed with any of the following drivers: Scer\GAL4^RapGAP1-OK6, Scer\GAL4^repo, Scer\GAL4^Toll-6-D42 or Scer\GAL4^DJ757.

Expression of RhoBTB^HMS00411 (with UAS-Dicer2) controlled by either Scer\GAL4^elav.PU or Scer\GAL4^Mef2.247 does not significantly impair either learning or short- or long-term memory tested in a courtship conditioning paradigm.

Expression of RhoBTB^HMS00411 (with UAS-Dicer2) under the combined control of Scer\GAL4⁴⁷⁷ and Scer\GAL4^ppk.PG leads to defects in the morphology of the dendritic arbor (reduced number as well as length of branches) of class IV dendritic arborizing neurons in third instar larvae.