FlyBase Allele Report: Dmel\gfzf[6a27]

General Information

Symbol

Dmel\gfzf^6a27

Species

D. melanogaster

Name

FlyBase ID

FBal0248348

Feature type

allele

Associated gene

Dmel\gfzf

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ambrus et al., 2009)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3R)ED5221)

(Ambrus et al., 2009)

lethal (with Df(3R)ED7665)

(Ambrus et al., 2009)

lethal (with gfzf^EY08448)

(Ambrus et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous cells in eye imaginal disc clones enter and exit the second mitotic wave at approximately the same time as adjacent wild-type cells.

(Ambrus et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG2656^KG08427, gfzf^6a27 has viable phenotype

(Ambrus et al., 2009)

CG2656^e00303, gfzf^6a27 has viable phenotype

(Ambrus et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

gfzf^6a27 is a suppressor of eye | somatic clone phenotype of E2f1^rM729

(Ambrus et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

gfzf^6a27 can suppress the proliferation block of E2f^rM729 clones, allowing recovery of double mutant clones in the eye.

The second mitotic wave is weakly rescued in gfzf^6a27 E2f^rM729 double mutant clones in the eye disc, with the double mutant cells entering the second mitotic wave several columns more posterior than in wild-type cells. In addition BrdU incorporation persists several columns more posterior in the double mutant cells than in the adjacent wild-type cells.

(Ambrus et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

gfzf²

(Ambrus et al., 2009)

gfzf^EY08448

(Ambrus et al., 2009)

gfzf^CZ811

(Ambrus et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

6a27

(Ambrus et al., 2009)

gfzf^6a27

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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