FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PlexAΔcyt.UAS
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General Information
Symbol
Dmel\PlexAΔcyt.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0248407
Feature type
allele
Associated gene
Dmel\PlexA
Associated Insertion(s)
Carried in Construct
P{UAS-PlexA.Δcyt}
Key Links
Transgenic product class
inframe_deletion
(Yu et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Yu et al., 2010)
Mutagen
in vitro construct
(Yu et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-PlexA.Δcyt}
Cytology
Description

A fragment of PlexA encoding for the amino acid sequence G785 to R1326 followed by a stop codon is cloned downstream of UAS regulatory sequences. This results in a transgene in which the cytoplasmic domain of PlexA is removed.

(Yu et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
PlexA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of plexAΔcyt.Scer\UAS in R-cell axons under the control of Scer\GAL4GMR.PF induces hyperfasciculation leading to the formation of thicker R-cell axonal bundles between lamina and medulla, and a decrease in the number of separate axonal bundles between lamina and medulla. In medulla, R-cell axons form large clumps.

      (Yu et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of plexAΔcyt.Scer\UAS in R-cells where endogenous plexA is knocked-down by expression of plexAdsRNA.Scer\UAS (both transgenes under the control of Scer\GAL4GMR.PF) largely restores the R1-R6 termination pattern in the lamina.

      (Yu et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PlexAΔcyt.Scer\UAS
      PlexAΔcyt.UAS
      plexAΔcyt.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)