FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fanRNAi.βTub85D
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General Information
Symbol
Dmel\fanRNAi.βTub85D
Species
D. melanogaster
Name
FlyBase ID
FBal0248447
Feature type
allele
Associated gene
Dmel\fan
Associated Insertion(s)
Carried in Construct
P{βTub85D-fan.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Ma et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ma et al., 2010)
Mutagen
in vitro construct
(Ma et al., 2010)
Progenitor genotype
Carried in construct
P{βTub85D-fan.RNAi}
Cytology
Description

βTub85D promoter sequences drive expression of an inverted-repeat of fan.

(Ma et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
βTub85D
Encoded product / tool
fan
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing fandsRNA.βTub85D display reduced fertility, and flies exhibit a rapid decline in fertility by 10 days after eclosion. In males testes, the individualisation complexes of spermatid bundles are severely disorganised.

      (Ma et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      fanRNAi.βTub85D has semi-sterile phenotype, suppressible by OsbpUAS.cMa/Scer\GAL4Hsp83.PA

      (Ma et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of OsbpScer\UAS.cMa under the control of Scer\GAL4Hsp83.PA significantly rescues the reduced fertility observed in fandsRNA.βTub85D animals.

      (Ma et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fanRNAi.βTub85D
      fandsRNA.βTub85D
      Name Synonyms
      Secondary FlyBase IDs
        References (2)