FlyBase Allele Report: Dmel\Tip60[RNAi.UAS.cSa]

General Information

Symbol

Dmel\Tip60^RNAi.UAS.cSa

Species

D. melanogaster

Name

FlyBase ID

FBal0248521

Feature type

allele

Associated gene

Dmel\Tip60

Associated Insertion(s)

Carried in Construct

P{UAS-Tip60.RNAi.S}

Key Links

Transgenic product class

RNAi_reagent

(Schirling et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Schirling et al., 2010)

Mutagen

in vitro construct

(Schirling et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Tip60.RNAi.S}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat of Tip60 sequences (nucleotides 191-1222 in the sense direction and nucleotides 250-1275 in the antisense direction).

(Schirling et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Tip60

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

lethal, with Scer\GAL4^da.G32

(Schirling et al., 2010)

lethal | heat sensitive, with Scer\GAL4^T80

(Schirling et al., 2010)

viable, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

visible, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

visible, with Scer\GAL4^T80

(Schirling et al., 2010)

Phenotype Manifest In

wing, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

wing, with Scer\GAL4^T80

(Schirling et al., 2010)

wing disc, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

wing vein | ectopic, with Scer\GAL4^en-e16E

(Schirling et al., 2010)

wing vein | ectopic, with Scer\GAL4^T80

(Schirling et al., 2010)

Detailed Description

Statement

Reference

Expression of Tip60^{Scer\UAS.Scer\UAS.cSa} under the control of Scer\GAL4^T80 results in more than 90% lethality at 29[o]C. Expression of Tip60^{Scer\UAS.Scer\UAS.cSa} under the control of Scer\GAL4^T80 at 27[o]C results in little lethality, but more than 90% of survivors have ectopic wing veins (which mostly run parallel to vein L5). At 25[o]C, no lethality is seen, and approximately 50% of adults have ectopic wing veins.

Expression of Tip60^{Scer\UAS.Scer\UAS.cSa} under the control of Scer\GAL4^en-e16E at 29[o]C results in approximately 50% of adults having ectopic wing veins.

Increased cell death is seen in the wing disc in animals expressing Tip60^{Scer\UAS.Scer\UAS.cSa} under the control of Scer\GAL4^en-e16E.

(Schirling et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tip60^RNAi.UAS.cSa

Tip60^{Scer\UAS.Scer\UAS.cSa}

Tip60^{dsRNA.UAS.cSa}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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