FB2026_03 , released September 17, 2026
Allele: Dmel\Snap25R206A.UAS
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General Information
Symbol
Dmel\Snap25R206A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0248542
Feature type
allele
Associated gene
Dmel\Snap25
Associated Insertion(s)
Carried in Construct
P{UAS-Snap25.R206A}
Key Links
Transgenic product class
missense_variant
(Megighian et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Megighian et al., 2010)
Mutagen
in vitro construct
(Megighian et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Snap25.R206A}
Cytology
Description

UASt regulatory sequences drive expression of a mutated Snap25 open reading frame which contains the amino acid replacement R206A.

(Megighian et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Snap25
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The frequency of spontaneous release (miniature end-plate potential (MEPP) frequency) at the neuromuscular junction is reduced in larvae expressing Snap25R206A.Scer\UAS under the control of Scer\GAL4elav.PU compared to larvae expressing Snap25WT.Scer\UAS under the control of Scer\GAL4elav.PU. The average MEPP amplitude of larvae expressing Snap25R206A.Scer\UAS under the control of Scer\GAL4elav.PU is not significantly different from that of larvae expressing Snap25WT.Scer\UAS under the control of Scer\GAL4elav.PU.

      The average frequency and amplitude of the miniature end plate current (MEPC) at the neuromuscular junction are both reduced in larvae expressing Snap25R206A.Scer\UAS under the control of Scer\GAL4elav.PU compared to larvae expressing Snap25WT.Scer\UAS under the control of Scer\GAL4elav.PU.

      The mean amplitude of evoked junctional potentials at the neuromuscular junction is reduced in larvae expressing Snap25R206A.Scer\UAS under the control of Scer\GAL4elav.PU compared to larvae expressing Snap25WT.Scer\UAS under the control of Scer\GAL4elav.PU.

      The total number of boutons per neuromuscular junction and the diameter of type 1b and 1s boutons at the neuromuscular junction in larvae expressing Snap25R206A.Scer\UAS under the control of Scer\GAL4elav.PU are not significantly from those in larvae expressing Snap25WT.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Megighian et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Snap25R206A.Scer\UAS
      Snap25R206A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)