FlyBase Allele Report: Dmel\Liprin-β[Δ83]

General Information

Symbol

Dmel\Liprin-β^Δ83

Species

D. melanogaster

Name

FlyBase ID

FBal0248999

Feature type

allele

Associated gene

Dmel\Liprin-β

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Astigarraga et al., 2010)

Mutagen

Delta2-3 transposase

(Astigarraga et al., 2010)

Progenitor genotype

P{EPgy2}Liprin-β^EY22999

(Astigarraga et al., 2010)

Cytology

Description

A 1.85kb deletion extending into the Liprin-β gene from the P{EPgy2}Liprin-β^EY22999 insertion site in the 5'UTR.

(Astigarraga et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:13,513,368..13,515,218 [+]

Comment:

Approximate endpoints of deletion of reported length 1.85kb, which extends from P{EPgy2}Liprin-beta^EY22999 into Liprin-beta.

(Astigarraga et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Astigarraga et al., 2010)

abnormal neuroanatomy (with Df(3L)BSC614)

(Astigarraga et al., 2010)

abnormal neuroanatomy (with Liprin-β^Δ51)

(Astigarraga et al., 2010)

Phenotype Manifest In

medulla

(Astigarraga et al., 2010)

medulla (with Df(3L)BSC614)

(Astigarraga et al., 2010)

medulla (with Liprin-β^Δ51)

(Astigarraga et al., 2010)

NMJ bouton | larval stage

(Astigarraga et al., 2010)

photoreceptor cell R7

(Astigarraga et al., 2010)

photoreceptor cell R7 (with Df(3L)BSC614)

(Astigarraga et al., 2010)

photoreceptor cell R7 (with Liprin-β^Δ51)

(Astigarraga et al., 2010)

Detailed Description

Statement

Reference

14-17% of R7 axons show projections extending beyond the M6 layer of the medulla in Liprin-β^Δ83, Liprin-β^Δ83/Liprin-β^Δ51 or Liprin-β^Δ83/Df(3L)BSC614 mutants.

The number of synaptic boutons at the muscle 6/7 synapses in abdominal segments A2 and A3 in Liprin-β^Δ83 animals is ~70% of that from control larvae.

(Astigarraga et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ83 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ83 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Liprin-β^Δ83 has NMJ bouton | larval stage phenotype, suppressible by Scer\GAL4^how-24B/trio^UAS.cBa

(Astigarraga et al., 2010)

Liprin-β^Δ83 has NMJ bouton | larval stage phenotype, suppressible by Scer\GAL4^elav-C155/trio^UAS.cBa

(Astigarraga et al., 2010)

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ83 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ83 has medulla phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ83 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Liprin-α^oos, Liprin-β^Δ83 has medulla phenotype

(Astigarraga et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

In Liprin-α^oos, Liprin-β^Δ83 double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla.

In Lar^unspecified, Liprin-β^Δ83 double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla.

Scer\GAL4^how-24B- or Scer\GAL4^elav-C155-mediated expression of trio^Scer\UAS.cBa restores the number of boutons in Liprin-β^Δ83 animals to control levels.

(Astigarraga et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Liprin-β^Δ83 is rescued by Scer\GAL4^how-24B/Liprin-β^UAS.Tag:HA

(Astigarraga et al., 2010)

Liprin-β^Δ83/Liprin-β^Δ51 is rescued by Scer\GAL4^elav-C155/Liprin-β^UAS.Tag:HA

(Astigarraga et al., 2010)

Partially rescued by

Liprin-β^Δ83/Liprin-β^Δ51 is partially rescued by Scer\GAL4^elav-C155/Liprin-β^UAS.Tag:HA

(Astigarraga et al., 2010)

Comments

Scer\GAL4^elav-C155-mediated expression of Liprin-β^{Scer\UAS.T:Ivir\HA1} significantly rescues the aberrant axon termination phenotype seen in Liprin-β^Δ83/Liprin-β^Δ51 mutants.

Scer\GAL4^elav-C155-mediated expression of Liprin-β^{Scer\UAS.T:Ivir\HA1} restores the number of boutons in Liprin-β^Δ83/Liprin-β^Δ51 animals to control levels.

Scer\GAL4^how-24B-mediated expression of Liprin-β^{Scer\UAS.T:Ivir\HA1} restores the number of boutons in Liprin-β^Δ83 animals to control levels.

(Astigarraga et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63810

w^*; Liprin-β^Δ83 P{FRT(w^hs)}2A

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Liprin-β^Δ83

(Astigarraga et al., 2010)

β^Δ83

(Astigarraga et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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