FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HcfRNAi.3.UAS
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General Information
Symbol
Dmel\HcfRNAi.3.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0249308
Feature type
allele
Associated gene
Dmel\Hcf
Associated Insertion(s)
Carried in Construct
P{UAS-Hcf.RNAi.3}
Key Links
Transgenic product class
RNAi_reagent
(Furrer et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Furrer et al., 2010)
Mutagen
in vitro construct
(Furrer et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Hcf.RNAi.3}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of sequences corresponding to Hcf amino acid residues 1058-1273.

(Furrer et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hcf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HcfdsRNA.IR-3.Scer\UAS under the control of Scer\GAL4sca-109-68 leads to a slight reduction in the size of the posterior scutellar bristles in females (no such effect is seen in males).

      (Furrer et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      HcfRNAi.3.UAS, Scer\GAL4ap-md544 is a suppressor | partially of visible phenotype of MycUAS.cZa, Scer\GAL4ap-md544

      (Furrer et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing defects caused by expression of dmScer\UAS.cZa under the control of Scer\GAL4ap-md544 are partially suppressed by co-expression of HcfdsRNA.IR-3.Scer\UAS.

      Co-expression of HcfdsRNA.IR-2.Scer\UAS strongly suppresses the excessive endoreplication seen in clones in the larval salivary glands expressing dmScer\UAS.cZa under the control of Scer\GAL4Act5C.PP.

      Clonal expression of HcfdsRNA.IR-3.Scer\UAS under the control of Scer\GAL4αTub84B.PBb in a dmP0 background results in flies with smaller ommatidia than normal.

      (Furrer et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HcfRNAi.3.UAS
      HcfRNAi.IR-3.UAS
      HcfdsRNA.IR-3.Scer\UAS
      HcfdsRNA.IR-3.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)