FB2026_02 , released June 18, 2026
Allele: Dmel\AGO2321
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General Information
Symbol
Dmel\AGO2321
Species
D. melanogaster
Name
FlyBase ID
FBal0249325
Feature type
allele
Associated gene
Dmel\AGO2
Associated Insertion(s)
P{?EP}AGO2321
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hain et al., 2010)
Mutagen
Delta2-3 transposase
(Hain et al., 2010)
Progenitor genotype
P{EP}AGO2EP3417
(Hain et al., 2010)
Associated Insertion(s)
P{?EP}AGO2321
Cytology
Description

Imprecise excision of the progenitor insertion resulting in a deletion of 2514bp. Part of the original inserted element remains.

(Hain et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:15,554,139..15,556,652 [+]
Comment:

2514 bp deletion resulting from the imprecise excision of P{EP}AGO2EP3417, which removes the first coding exon of AGO2 and most of the first intron. Part of the original insertion remains.

(Hain et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      AGO2321/Df(3L)BSC558 males show dramatically reduced numbers of mature sperm in their seminal vesicles. The spermatid nuclear alignment as well as the alignment of the investment cones in the testes is strongly disrupted.

      (Wen et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from dop1/AGO2321 transheterozygous females hatch and have a normal pattern lipid-droplet distribution.

      (Hain et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3L)BSC558/AGO2321 is rescued by AGO2Tag:FLAG,Tag:HA

      (Wen et al., 2015)
      Comments

      The sperm deficiency of AGO2321/Df(3L)BSC558 mutant males is rescued by combination with AGO2T:Zzzz\FLAG,T:Ivir\HA1.

      (Wen et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      dop1 complements AGO2321.

      (Hain et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      321
      (Harbison et al., 2019)
      AGO2321
      (Fort-Aznar et al., 2020, Lee et al., 2018)
      Ago-2321
      (Harsh et al., 2018)
      Ago2321
      (Merkling et al., 2019)
      ago2321
      (Schmidts et al., 2016, Wen et al., 2015, Hain et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)