FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CASKP46
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General Information
Symbol
Dmel\CASKP46
Species
D. melanogaster
Name
FlyBase ID
FBal0249408
Feature type
allele
Associated gene
Dmel\CASK
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Slawson et al., 2011)
Mutagen
Delta2-3 transposase
(Slawson et al., 2011)
Progenitor genotype
P{EPgy2}CASKEY07081
(Slawson et al., 2011)
Cytology
Description

Excision of P{EPgy2}CASKEY07081, resulting in a 2284 bp deletion of 5'UTR and the entire first coding exon of CASK. This first exon contains the translational start site an the first 20 codons of the ORF.

(Slawson et al., 2011)

Lacks full-length mRNA for the CASK-β isoform (corresponding to CASK-PB and CASK-PF), though mRNA for the small CASK-α isoform (corresponding to CASK-PA, CASK-PD and CASK-PE) is expressed.

(Slawson et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CASKP46 mutants exhibit a significant reduction of acquired tolerance to ethanol vapor-induced sedation, and a significant increase in ethanol sensitivity, as compared to controls.

      (Maiya et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CASKP46
      (Maiya et al., 2012)
      P46
      (Slawson et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)