FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rheaR367A.Ubi-p63E
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General Information
Symbol
Dmel\rheaR367A.Ubi-p63E
Species
D. melanogaster
Name
FlyBase ID
FBal0256724
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
P{Ubi-p63E-talin.R367A}
Key Links
Transgenic product class
missense_variant
(Tanentzapf and Brown, 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tanentzapf and Brown, 2006)
Mutagen
in vitro construct
(Tanentzapf and Brown, 2006)
Progenitor genotype
Carried in construct
P{Ubi-p63E-talin.R367A}
Cytology
Description

Ubi-p63E promoter sequences drive expression of full-length rhea (sequence extends from 457bp upstream of the ATG codon to 100bp downstream of the stop codon) containing the amino acid replacement R367A.

(Tanentzapf and Brown, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
rhea
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing rheaR367A.Ubi-p63E in a Df(3L)79a mutant background display a late-muscle-detachment phenotype.

      (Tanentzapf and Brown, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ifΔGFFNR.Scer\UAS under the control of Scer\GAL4how-24B rescues the late-muscle-detachment phenotype of embryos expressing rheaR367A.Ubi-p63E in a Df(3L)79a mutant background.

      (Tanentzapf and Brown, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      rheaR367A.Ubi-p63E partially rescues Df(3L)79a

      (Tanentzapf and Brown, 2006)
      Comments

      Expression of rheaR367A.Ubi-p63E fails to rescue the lethality of of Df(3L)79a germ-line clones. However, expression does rescue defects in gut migration, germ-band retraction, dorsal closure, and muscle attachment. Late-onset muscle detachment is observed in these animals. Retraction of one end of some of the ventral longitudinal muscles from the attachment site is observed.

      (Tanentzapf and Brown, 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rheaR367A.Ubi-p63E
      Name Synonyms
      Secondary FlyBase IDs
        References (2)