FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BmcpUAS.cBa
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General Information
Symbol
Dmel\BmcpUAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0256733
Feature type
allele
Associated gene
Dmel\Bmcp
Associated Insertion(s)
Carried in Construct
P{UAS-Bmcp.B}
Key Links
Transgenic product class
cDNA
(Besson et al., 2010)
wild_type
(Besson et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Besson et al., 2010)
wild_type
(Besson et al., 2010)
Mutagen
in vitro construct
(Besson et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Bmcp.B}
Cytology
Description

UASt drives expression of a full-length Bmcp cDNA.

(Besson et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Bmcp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Besson et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Expression of BmcpScer\UAS.cBa rescues glial pathology but failed to alleviate neuronal defects in the Hsap\HTTQ93.ex1p.Scer\UAS model of Huntington’s disease.

      (Besson et al., 2010)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No change in lifespan is observed when BmcpScer\UAS.cBa is expressed using Scer\GAL4repo or Scer\GAL4elav-C155.

      (Besson et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      When BmcpScer\UAS.cBa is co-expressed in the Hsap\HTTQ93.ex1p.Scer\UAS, Scer\GAL4repo background, locomotor defects are suppressed: 52% of flies reach the top of the column after a startle while <22% remain at the bottom.

      When BmcpScer\UAS.cBa is co-expressed in the Hsap\HTTQ93.ex1p.Scer\UAS, Scer\GAL4repo background, bang sensitivity is suppressed: only 23% of flies are bang sensitive.

      Co-expression of BmcpScer\UAS.cBa improves extends the lifespan of Hsap\HTTQ93.ex1p.Scer\UAS, Scer\GAL4repo flies: >78% of these flies are alive at 16 days, and life expectancy is increased by 23-25%.

      Co-expression of BmcpScer\UAS.cBa increases the life expectancy of Hsap\HTTQ93.ex1p.Scer\UAS, Scer\GAL4Eaat1.PR flies by 20%.

      Co-expression of BmcpScer\UAS.cBa does not improve the climbing ability or lifespan phenotypes of Hsap\HTTQ93.ex1p.Scer\UAS, Scer\GAL4elav-C155 flies.

      (Besson et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BmcpScer\UAS.cBa
      BmcpUAS.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)