FlyBase Allele Report: Dmel\fd3F[1]

General Information

Symbol

Dmel\fd3F¹

Species

D. melanogaster

Name

FlyBase ID

FBal0256940

Feature type

allele

Associated gene

Dmel\fd3F

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Newton et al., 2012)

Mutagen

P-element activity

(Cachero et al., 2011)

Progenitor genotype

fd3F^EP1198

(Cachero et al., 2011)

Cytology

Description

Deletion of 1.4kb that removes approximately 400bp of the 3' end of the fd3F open reading frame.

(Newton et al., 2012)

Imprecise excision of P{EP}fd3F^EP1198 deletes the 3' end of the fd3F transcription unit.

(Cachero et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception | adult stage

(Newton et al., 2012)

abnormal locomotor behavior

(Cachero et al., 2011)

abnormal locomotor behavior | adult stage | recessive

(Newton et al., 2012)

abnormal neuroanatomy | adult stage

(Newton et al., 2012)

abnormal neuroanatomy | embryonic stage

(Newton et al., 2012)

abnormal neurophysiology | adult stage

(Newton et al., 2012)

Phenotype Manifest In

chordotonal neuron | embryonic stage

(Newton et al., 2012)

Johnston organ neuron

(Newton et al., 2012)

scolopidial cilium

(Newton et al., 2012)

Detailed Description

Statement

Reference

Homozygous adults perform very poorly in a climbing assay.

Mutant flies show no sound-evoked compound action potentials in the projections of Johnston's organ neurons in the antennal nerve. Analysis of the mechanical response of the antennal sound receiver to tones of different intensities indicates that chordotonal organ cilium motility is lost.

The chordotonal cilium of the Johnston's organ lacks the dynein outer and inner arms in the proximal region.

Cilia of embryonic chordotonal neurons show abnormal dilation.

(Newton et al., 2012)

fd3F¹ mutant larvae and adult flies exhibit locomotion defects. Ch neurons are mostly specified normally in fd3F¹ mutants, with little gross structural defects observed in these mutants.

(Cachero et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Fd3F¹

(Zur Lage et al., 2018)

fd3F¹

(Diggle et al., 2014, Moore et al., 2013, Newton et al., 2012, Cachero et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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