FlyBase Allele Report: Dmel\Ctr9[HMS00619]

General Information

Symbol

Dmel\Ctr9^HMS00619

Species

D. melanogaster

Name

FlyBase ID

FBal0257304

Feature type

allele

Associated gene

Dmel\Ctr9

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00619}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00619}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00619

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^49.UAS

(Goodman et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis | progressive, with Scer\GAL4^{VP16.nanos.UTR}

(Chaturvedi et al., 2016)

lethal, with Scer\GAL4^da.PU

(Chaturvedi et al., 2016)

male sterile, with Scer\GAL4^VP16.bam

(Vilstrup et al., 2024)

Phenotype Manifest In

germarium | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Chaturvedi et al., 2016)

germarium | oogenesis | progressive, with Scer\GAL4^{VP16.nanos.UTR}

(Chaturvedi et al., 2016)

germ cell nucleus | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Chaturvedi et al., 2016)

Detailed Description

Statement

Reference

The expression of Ctr9^HMS00619 under the control of Scer\GAL4^da.PU leads to lethality; expression under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} leads to the progressive loss of germline cells from the germarium, the nuclei of which exhibit severe morphological defects and polyploidy, as compared to controls.

(Chaturvedi et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33736

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00619}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG2469^HMS00619

Ctr9^HMS00619

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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