FlyBase Allele Report: Dmel\DnaJ-1[HMS00688]

General Information

Symbol

Dmel\DnaJ-1^HMS00688

Species

D. melanogaster

Name

FlyBase ID

FBal0257371

Feature type

allele

Associated gene

Dmel\DnaJ-1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00688}

Also Known As

DnaJ-1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00688}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00688

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tsou et al., 2015)

modeled by Hsap\ATXN3^{UbS2-mild.fl.SCA3.UAS}

(Sutton et al., 2017)

exacerbates Creutzfeldt-Jakob disease

modeled by Oari\PrP^VRQ.UAS

(Thackray et al., 2022)

modeled by Hsap\PRNP^M129.UAS.cTa

(Thackray et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

DnaJ-1^HMS00688, Scer\GAL4^GMR.long is an enhancer of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Other

Statement

Reference

DnaJ-1^HMS00688, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

DnaJ-1^HMS00688, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Other

Statement

Reference

DnaJ-1^HMS00688, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of DnaJ-1^HMS00688 suppresses the protective role of expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} in suppressing eye degeneration in flies with Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.long. Co-expression of DnaJ-1^HMS00688 enhances eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

(Tsou et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32899

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00688}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

DnaJ-1^HMS00688

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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