FlyBase Allele Report: Dmel\hth[HMS01112]

General Information

Symbol

Dmel\hth^HMS01112

Species

D. melanogaster

Name

FlyBase ID

FBal0257775

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01112}

Also Known As

UAS-hth RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01112}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01112

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4¹¹⁵¹

(Bryantsev et al., 2012)

Phenotype Manifest In

extracoxal trochanter depressor muscle cell | ectopic, with Scer\GAL4¹¹⁵¹

(Bryantsev et al., 2012)

eye, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

flight muscle cell, with Scer\GAL4¹¹⁵¹

(Bryantsev et al., 2012)

maxillary palp | somatic clone, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

vibrissal bristle, with Scer\GAL4^dpp.s-hc

(Stultz et al., 2012)

Detailed Description

Statement

Reference

Flies expressing hth^HMS01112 under the control of Scer\GAL4¹¹⁵¹ show a striking transformation of the flight muscles into a jump muscle fate. Compared to wild-type, the sizes of the jump muscles are strongly reduced in the mutants.

(Bryantsev et al., 2012)

Expression of lab^JF02317 under the control of Scer\GAL4^dpp.s-hc produces vibrissae defects, round bulging eyes with loss of cuticle tissue, and loss of maxillary palps.

(Stultz et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/hth^HMS01112 is a suppressor of neoplasia | somatic clone phenotype of scrib⁶⁷³

(Khan et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/hth^HMS01112 is a non-suppressor of neoplasia | somatic clone phenotype of Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa

(Khan et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/hth^HMS01112 is a suppressor of eye disc | somatic clone phenotype of scrib⁶⁷³

(Khan et al., 2013)

NOT Suppressor of

Statement

Reference

hth^HMS01112/Scer\GAL4^tin.CΔ4 is a non-suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, yki^{S168A.UAS.Tag:V5}

(Yu et al., 2015)

Scer\GAL4^Tub.PU/hth^HMS01112 is a non-suppressor of wing disc | distal | somatic clone phenotype of Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa

(Khan et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of hth^HMS01112 does not suppress the cardiac hypertrophy seen when yki^{S168A.Scer\UAS.T:SV5\V5} is expressed under the control of Scer\GAL4^tin.CΔ4.

(Yu et al., 2015)

Expression of hth^HMS01112 does not suppress the overproliferation and neoplastic transformation seen in both the proximal and distal wing disc domains when yki^Scer\UAS.cHa is expressed under the control of Scer\GAL4^tub.PU in l(2)gl⁴ mutant clones.

Expression of hth^HMS01112 under the control of Scer\GAL4^tub.PU suppresses the neoplastic transformation seen in scrib⁶⁷³ mutant eye disc clones.

(Khan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington