FlyBase Allele Report: Dmel\mav[HMS01125]

General Information

Symbol

Dmel\mav^HMS01125

Species

D. melanogaster

Name

FlyBase ID

FBal0257788

Feature type

allele

Associated gene

Dmel\mav

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01125}

Also Known As

UAS-mav^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01125}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01125

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS

(Beckwith et al., 2013)

abnormal neuroanatomy | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

abnormal size | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

abnormal size | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

Phenotype Manifest In

dendritic tree | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

larval multidendritic class IV neuron | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^A58

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^NP0022

(Hoyer et al., 2018)

Detailed Description

Statement

Reference

The expression of mav^HMS01125 under the control of Scer\GAL4^en-e16E leads to longer dendrites in the posterior dendrite region of third instar larval C4da neurons, but not in the anterior dendritic region or the overall dendrite length, as compared to controls.

Expression of mav^HMS01125 under the control of Scer\GAL4^NP0022 leads to shorter and longer dendrites in the dorsal and ventral dendritic region, respectively, of larval C4da neurons, but does not affect the overall dendrite length, as compared to controls.

Upon clonal expression of mav^HMS01125 under the control of Scer\GAL4^Act.PU, C4da neurons exhibit shorter dendrites mainly in regions covering mav^UAS.cGa-expressing epithelial cells; the higher bigger the epithelial clone area, the higher the effect observed on dendrites covering non-expressing cells.

Expression of mav^HMS01125 under the control of Scer\GAL4^A58 leads to third instar larval C4da neurons exhibiting a less complex dendrite tree (i.e. significantly less dendritic coverage and significantly shorter dendrites), as compared to controls.

(Hoyer et al., 2018)

Down-regulation of mav in Pdf-positive neurons, through expression of mav^HMS01125 under the control of Scer\GAL4^P2.4.Pdf induces strong locomotor arrhythmicity. Expression of mav^HMS01125 under the control of Scer\GAL4^tim.PE and suppressed in Pdf-positive cells through the presence of Scer\GAL80^Pdf.PS results in some rescue of the arrhythmic phenotype.