FlyBase Allele Report: Dmel\chb[HMS01146]

General Information

Symbol

Dmel\chb^HMS01146

Species

D. melanogaster

Name

FlyBase ID

FBal0257807

Feature type

allele

Associated gene

Dmel\chb

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01146}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01146}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01146

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dendritic microtubule, with Scer\GAL4^221w-

(Yagoubat and Conduit, 2025)

Golgi apparatus, with Scer\GAL4^221w-

(Yagoubat and Conduit, 2025)

Detailed Description

Statement

Reference

Cells expressing chb^HMS01146 under the control of Scer\GAL4^Act5C.PP in mosaic follicular epithelia do not exhibit defects in trailing edge retraction, as compared to control cells.

(Barlan et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^ap-md544/chb^HMS01146 is an enhancer of abnormal size | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^ap-md544/chb^HMS01146 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, chb^HMS01146 has centrosome | increased number | third instar larval stage phenotype

(Gerlach et al., 2018)

BacA\p35^UAS.cHa, Scer\GAL4^ap-md544, chb^HMS01146 has wing disc dorsal compartment | third instar larval stage phenotype

(Gerlach et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of chb^HMS01146 enhances the third instar larval wing disc dorsal compartment enlargement induced by the expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts].

(Gerlach et al., 2018)

Xenogenetic Interactions

Statement

Reference

The co-expression of chb^HMS01146 and BacA\p35^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] leads to a significant increase in the average number of centrosomes per cell in the third instar larval wing disc dorsal compartment, as compared to controls.

(Gerlach et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34669

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01146}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

chb^HMS01146

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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