FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ntl129A
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General Information
Symbol
Dmel\Ntl129A
Species
D. melanogaster
Name
FlyBase ID
FBal0258102
Feature type
allele
Associated gene
Dmel\Ntl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chatterjee et al., 2011)
Mutagen
Delta2-3 transposase
(Chatterjee et al., 2011)
Progenitor genotype
P{EPgy2}NtlEY05549
(Chatterjee et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion P{EPgy2}NtlEY05549 results in a mutation in Ntl.

(Chatterjee et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early sperm development appears normal in Ntl129A mutant testes. The individualisation process and axoneme structure appear normal. Males produce elongated spermiogenic cysts, but no mature sperm is detected in the seminal vesicle. No motile sperm are observed in squash preparations. An extensive mass of coiled sperm bundles accumulate at the base of Ntl129A mutant testes.

      (Chatterjee et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ntl129A is rescued by NtlβTub85D

      (Chatterjee et al., 2011)

      Ntl129A is rescued by Ntl+t6

      (Chatterjee et al., 2011)
      Comments

      Expression of NtlβTub85D restores fertility in Ntl129A mutant males.

      (Chatterjee et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ntl129A
      (Chatterjee et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)