FB2026_02 , released June 18, 2026
Allele: Dmel\CblL.mPR.Hsp83
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General Information
Symbol
Dmel\CblL.mPR.Hsp83
Species
D. melanogaster
Name
FlyBase ID
FBal0258207
Feature type
allele
Associated gene
Dmel\Cbl
Associated Insertion(s)
Carried in Construct
P{Hsp83-Cbl.L.mPR}
Key Links
Transgenic product class
missense_variant
(Wang and Pai, 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang and Pai, 2011)
Mutagen
in vitro construct
(Wang and Pai, 2011)
Progenitor genotype
Carried in construct
P{Hsp83-Cbl.L.mPR}
Cytology
Description

Hsp83 promoter sequences drive expression of the long Cbl isoform carrying a modified PPLPPR motif, where the first and fifth prolines are replaced with alanines (APLPAR).

(Wang and Pai, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp83
Encoded product / tool
Cbl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      CblL.mPR.Hsp83 rescues CblF165

      (Wang and Pai, 2011)
      Partially rescues

      CblL.mPR.Hsp83 partially rescues CblF165

      (Wang et al., 2015)
      Comments

      Expression of CblL.mPR.Hsp83 in the follicle cell somatic clones homozygous for CblF165 partially rescues the loss of cytoophidia in stage 9 egg chambers - the proportion of cells completely lacking cytoophidia is significantly decreased.

      (Wang et al., 2015)

      Expression of CblL.mPR.Hsp83 rescues the lethality of CblF165, and 75-80% of animals develop to adults.

      (Wang and Pai, 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CblL.mPR.Hsp83
      Name Synonyms
      Secondary FlyBase IDs
        References (2)