FlyBase Allele Report: Dmel\Kdm5[gJmjC.mut]

General Information

Symbol

Dmel\Kdm5^gJmjC.mut

Species

D. melanogaster

Name

FlyBase ID

FBal0258315

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{gLid-JmjC.mut}

Key Links

Transgenic product class

missense_variant

(Li et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Li et al., 2010)

Mutagen

in vitro construct

(Li et al., 2010)

Progenitor genotype

Carried in construct

P{gLid-JmjC.mut}

Cytology

Description

Contains a 4.5kb XhoI fragment containing the lid upstream region and part of the coding region and a 4.8Kb XhoI/NotI cDNA fragment containing the remainder of the lid coding sequence, which has been mutated to contain two point mutations in the JmjC domain that prevent Fe[2+] binding (amino acid replacements H637A and E639A).

(Li et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

Kdm5

Encoded product / tool

Kdm5

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive | male, with Kdm5^unspecified

(Li et al., 2010)

short lived | male, with Kdm5^unspecified

(Li et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

lid^k06801 mutant flies rescued with lid^gJmjC.mut do not show any mitochondrial abnormalities in the thoracic muscles.

(Liu and Secombe, 2015)

lid^unspecified mutant males rescued by lid^gJmjC.mut have a significantly shorter lifespan that wild-type controls, while lid^unspecified mutant females rescued by lid^gJmjC.mut have a mean lifespan that is not significantly different to wild type.

lid^unspecified mutant males rescued by lid^gJmjC.mut are sensitive to paraquat compared to controls, while lid^unspecified mutant females rescued by lid^gJmjC.mut have normal sensitivity to paraquat.

(Li et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Kdm5^gJmjC.mut rescues Kdm5^k06801/Kdm5¹⁰⁴²⁴

(Zhaunova et al., 2016)

Partially rescues

Kdm5^gJmjC.mut partially rescues Kdm5¹⁰⁴²⁴

(DiTacchio et al., 2011)

Comments

Expression of lid^gJmjC.mut rescues the karyosome, centromere clustering and synaptonemal complex defects seen in the ovaries of lid^k06801/lid¹⁰⁴²⁴ mutants.

(Zhaunova et al., 2016)

Expression of lid^gJmjC.mut partially rescues the locomotor rhythm defects seen in homozygous lid¹⁰⁴²⁴ mutant flies. Under LD (12 hours of light:12 hours of dark) and DD conditions (constant darkness) flies exhibit attenuated day:night differences in activity, with flies showing increased activity around midday and reduced dark anticipation.

(DiTacchio et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Kdm5^gJmjC.mut

kdm5^JmjC

(Liu and Secombe, 2015)

lid^JmjC*

(Zhaunova et al., 2016)

lid^gJmjC.mut

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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