FB2026_02 , released June 18, 2026
Allele: Hsap\OPRM1UAS.Tag:FLAG
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General Information
Symbol
Hsap\OPRM1UAS.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0258373
Feature type
allele
Associated gene
Hsap\OPRM1
Associated Insertion(s)
Carried in Construct
P{UAS-FLAG-hOPRM1}
Key Links
Transgenic product class
wild_type
(Sellami et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sellami et al., 2010)
Mutagen
in vitro construct
(Sellami et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-FLAG-hOPRM1}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\OPRM1 coding sequences tagged at the N-terminus with Tag:FLAG.

(Sellami et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\OPRM1
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4IFa.PT does not generate male-male sexual behavior with or without application of fentanyl or methadone.

      Expression of Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG in Akh neuroendocrine cells under the control of Scer\GAL4Akh.PL increases the level of whole body trehalose independently of application of a mu agonist (methadone).

      Expression of Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG in the adult fat body under the control of Scer\GAL4Crz.PS increases the level of whole body trehalose independently of application of a mu agonist (methadone). There is no synergistic effect of expression of Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG under the control of both Scer\GAL4Akh.PL and Scer\GAL4Crz.PS. Whole body glycogen levels are also increased in these flies.

      Expression of Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG in non-peptidergic cells of the adult fat body under the control of Scer\GAL4Lsp2.PH increases the level of whole body trehalose.

      Flies expressing Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Akh.PL appear to be more hungry than controls, as defined by the amount of sugar water taken by male flies.

      (Sellami et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\OPRM1Scer\UAS.T:Zzzz\FLAG
      Hsap\OPRM1UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)