FB2026_02 , released June 18, 2026
Allele: Dmel\Klp61FUbi-p63E.GFP
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General Information
Symbol
Dmel\Klp61FUbi-p63E.GFP
Species
D. melanogaster
Name
Ubiquitin-63E promoter construct of Cheerambathur
FlyBase ID
FBal0258550
Feature type
allele
Associated gene
Dmel\Klp61F
Associated Insertion(s)
Carried in Construct
P{Ubi-Klp61F.GFP}
Also Known As
KLP61F-GFP
Key Links
Transgenic product class
wild_type
(Cheerambathur et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Cheerambathur et al., 2008)
Mutagen
in vitro construct
(Cheerambathur et al., 2008)
Progenitor genotype
Carried in construct
P{Ubi-Klp61F.GFP}
Cytology
Description

Ubi-p63E regulatory sequences drive expression of Klp61F tagged with GFP.

(Cheerambathur et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
Klp61F
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\MAPTUAS.0N4R.Tag:FLAG
      (Bougé and Parmentier, 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Klp61FUbi-p63E.T:Avic\GFP rescues the lethality of homozygous Klp61F07012 and trans-heterozygous Klp61F07012/Klp61F06836 mutants. The rescued flies are fertile and can be propagated as stable transgenic lines. The rescued embryos display a decrease in the rate of prometaphase-to-metaphase spindle elongation compared with wild type embryos, which leads to a small decrease in subsequent spindle length.

      (Cheerambathur et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The rough eye phenotype (missing interommatidial bristles) characteristic for flies expressing Hsap\MAPTScer\UAS.0N4R.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PU can be almost completely suppressed (hardly any bristles missing) by expression of Klp61FUbi-p63E.T:Avic\GFP.

      (Bougé and Parmentier, 2016)
      Complementation and Rescue Data
      Rescues

      Klp61FUbi-p63E.GFP rescues Klp61F06836/Klp61F07012

      (Cheerambathur et al., 2008)

      Klp61FUbi-p63E.GFP rescues Klp61F07012

      (Cheerambathur et al., 2008)
      Comments

      Klp61FUbi-p63E.T:Avic\GFP rescues the lethality of homozygous Klp61F07012 and trans-heterozygous Klp61F07012/Klp61F06836 mutants. The rescued flies are fertile and can be propagated as stable transgenic lines. The rescued embryos display a decrease in the rate of prometaphase-to-metaphase spindle elongation compared with wild type embryos, which leads to a small decrease in subsequent spindle length.

      (Cheerambathur et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Klp61FUbi-p63E.GFP
      Klp61FUbi-p63E.T:Avic\GFP
      Name Synonyms
      Ubiquitin-63E promoter construct of Cheerambathur
      Secondary FlyBase IDs
        References (6)