FlyBase Allele Report: Mdoa\Ace[UAS.cKa]

General Information

Symbol

Mdoa\Ace^UAS.cKa

Species

M. domestica

Name

FlyBase ID

FBal0258601

Feature type

allele

Associated gene

Mdoa\Ace

Associated Insertion(s)

Carried in Construct

P{UAS-MdAChE.K}

Transgenic product class

wild_type

(Kim et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kim et al., 2011)

Mutagen

in vitro construct

(Kim et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-MdAChE.K}

Cytology

Description

UAS regulatory sequences drive expression of coding sequences corresponding to the Mdoa\Ace open reading frame.

(Kim et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mdoa\Ace

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^C164

(Kim et al., 2011)

abnormal neuroanatomy, with Scer\GAL4^ChAT.7.4

(Kim et al., 2011)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Kim et al., 2011)

short lived | chemical conditional, with Scer\GAL4^C164

(Kim et al., 2011)

Phenotype Manifest In

synapse, with Scer\GAL4^C164

(Kim et al., 2011)

synapse, with Scer\GAL4^ChAT.7.4

(Kim et al., 2011)

synapse, with Scer\GAL4^elav-C155

(Kim et al., 2011)

Detailed Description

Statement

Reference

Overexpression of Mdoa\Ace^Scer\UAS.cKa in neuromuscular junctions under the control of Scer\GAL4^elav-C155, Scer\GAL4^C164 or Scer\GAL4^Cha.7.4 does not affect the number of synaptic boutons but does significantly increase the normalized length of synaptic branches.

When raised on 0.5ppm DDVP, an acetylcholine esterase inhibitor, Scer\GAL4^C164/Mdoa\Ace^Scer\UAS.cKa larvae show significantly increased survival rates compared with controls.

(Kim et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^C164/Mdoa\Ace^UAS.cKa is a suppressor of abnormal neuroanatomy phenotype of Ace^PL00568

(Kim et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^C164/Mdoa\Ace^UAS.cKa is a suppressor of NMJ bouton phenotype of Ace^PL00568

(Kim et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Overexpression of Mdoa\Ace^Scer\UAS.cKa in Ace^PL00568 mutant neuromuscular junctions under the control of Scer\GAL4^C164 rescues the normalized number of synaptic boutons and the length of synaptic branches.

(Kim et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mdoa\Ace^Scer\UAS.cKa

Mdoa\Ace^UAS.cKa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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