FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\aPKCS330A.T422A.UAS
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General Information
Symbol
Dmel\aPKCS330A.T422A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258618
Feature type
allele
Associated gene
Dmel\aPKC
Associated Insertion(s)
Carried in Construct
P{UAS-aPKC.S330A.T422A}
Key Links
Transgenic product class
missense_variant
(Kaplan et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kaplan et al., 2011)
Mutagen
in vitro construct
(Kaplan et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-aPKC.S330A.T422A}
Cytology
Description

Amino acid replacement: S330A.

(Kaplan et al., 2011)

UAS regulatory sequences drive expression of aPKC coding sequences in which the two predicted sgg consensus sites (S330A and T422A) are mutated.

(Kaplan et al., 2011)

Amino acid replacement: T422A.

(Kaplan et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
aPKC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of aPKCS330A.T422A.Scer\UAS under the control of Scer\GAL4da.G32 does not cause any apparent apical-basal phenotype but does cause denticle alignment defects.

      (Kaplan et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      aPKCS330A.T422A.UAS/Scer\GAL4da.G32 rescues aPKCk06403

      (Kaplan et al., 2011)
      Comments

      Expression of aPKCS330A.T422A.Scer\UAS under the control of Scer\GAL4da.G32 rescues the mild denticle organization defects found in aPKCk06403 mutants.

      (Kaplan et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      aPKCS330A.T422A.Scer\UAS
      aPKCS330A.T422A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)