FlyBase Allele Report: Dmel\lic[d13]

General Information

Symbol

Dmel\lic^d13

Species

D. melanogaster

Name

FlyBase ID

FBal0258644

Feature type

allele

Associated gene

Dmel\lic

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Cully et al., 2010)

Mutagen

P-element activity

(Cully et al., 2010)

Progenitor genotype

P{EP}lic^GE1091

(Cully et al., 2010)

Cytology

Description

Imprecise excision of P{EP}lic^GE1091 resulting in removal of 1411 nucleotides, including those encoding the initiating methionine and the first 351 nucleotides of the lic coding sequence.

(Cully et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:13,090,426..13,091,836 [+]

Comment:

1411 bp deletion resulting from the imprecise excision of P{EP}lic^GE1091 which removes the ATG start codon and 351 nucleotides of the lic coding sequence.

(Cully et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates hematologic cancer

modeled by hop^{UAS.ORF.Tag:HA}

(Terriente-Félix et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | third instar larval stage

(Cully et al., 2010)

decreased cell size | cell autonomous | somatic clone

(Cully et al., 2010)

lethal - all die before end of larval stage

(Cully et al., 2010)

some die during third instar larval stage

(Cully et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

lic^d13 mutant larvae do not display a melanotic phenotype in the posterior hindgut, either under normal food conditions or in response to salt stress.

(Seisenbacher et al., 2011)

lic^d13/Y flies die 96-120 hours after egg lay, around larval stage L3.

Adult survival is normal when heterozygous larvae are raised on food containing high salt, or when adult heterozygotes are exposed to hydrogen peroxide, dry starvation, or high temperatures.

lic^d13/Y third instar larvae are smaller than lic^d13/FM7 larvae.

lic^d13 wing disc clones contain cells that are approximately 15% smaller than heterozygous cells in the same tissue. In contrast, their cell cycle profiles are wild type.

(Cully et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

MKK3^d13

(Seisenbacher et al., 2011)

lic^D13

(Terriente-Félix et al., 2017)

lic^d13

(Santabárbara-Ruiz et al., 2015, Cully et al., 2010)

lic^null

(Terriente-Félix et al., 2017)

licorne^d13

(Seisenbacher et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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