FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NmdmcKK102478
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General Information
Symbol
Dmel\NmdmcKK102478
Species
D. melanogaster
Name
FlyBase ID
FBal0259173
Feature type
allele
Associated gene
Dmel\Nmdmc
Associated Insertion(s)
Carried in Construct
P{KK102478}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK102478}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK102478
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by park25
      (Celardo et al., 2017)
      modeled by Pink1B9
      (Celardo et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing NmdmcKK102478 under the control of Scer\GAL4da.PU display reduced eclosion rate compared to controls; the adults that manage to eclose show decreased lifespan and severely climbing ability defects.

      (Celardo et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4da.PU/NmdmcKK102478 is a non-enhancer of partially lethal phenotype of Pink1B9

      (Celardo et al., 2017)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4da.PU/NmdmcKK102478 is an enhancer of adult thorax phenotype of Pink1B9

      (Celardo et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality, dented thorax phenotype as well as climbing defects of Pink1B9 mutants is enhanced upon Scer\GAL4da.PU-driven expression NmdmcKK102478. A strong increase in lethality of park25 mutants is also seen upon expression of NmdmcKK102478 (hardly any adults can be recovered).

      (Celardo et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NmdmcKK102478
      Name Synonyms
      Secondary FlyBase IDs
        References (3)