FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Nmdmc
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General Information
Symbol
Dmel\Nmdmc
Species
D. melanogaster
Name
NAD-dependent methylenetetrahydrofolate dehydrogenase
Annotation Symbol
CG18466
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010222
Gene Model Status
Current
Stock Availability
12 publicly available
Enzyme Name (EC)
methylenetetrahydrofolate dehydrogenase (NAD(+)) (1.5.1.15)
methylenetetrahydrofolate dehydrogenase (NADP(+)) (1.5.1.5)
methenyltetrahydrofolate cyclohydrolase (3.5.4.9)
Gene Summary
May play a role in spermatogenesis. (UniProt, Q04448)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DNMDMC

Key Links
Genomic Location
Cytogenetic map
85C3-85C3
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:9042508..9050555
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables catalytic activity
inferred from electronic annotation with InterPro:IPR020867
(InterPro Project Members, 2004-)
enables magnesium ion binding
inferred from sequence or structural similarity with UniProtKB:P13995
(Price and Laughon, 1993)
enables methenyltetrahydrofolate cyclohydrolase activity
inferred from biological aspect of ancestor with PANTHER:PTN000002250
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P09440
(Gene Ontology Curators, 2002-)
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity
inferred from biological aspect of ancestor with PANTHER:PTN002224686
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P13995
(Price and Laughon, 1993)
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity
inferred from biological aspect of ancestor with PANTHER:PTN000002250
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P13995
(Price and Laughon, 1993)
inferred from electronic annotation with InterPro:IPR000672, InterPro:IPR020630, InterPro:IPR020631
(InterPro Project Members, 2004-)
enables phosphate ion binding
inferred from sequence or structural similarity with UniProtKB:P13995
(Price and Laughon, 1993)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in tetrahydrofolate interconversion
inferred from biological aspect of ancestor with PANTHER:PTN000002250
(GO Reference Genome Project, 2011-)
involved_in tetrahydrofolate metabolic process
inferred from sequence or structural similarity with UniProtKB:P13995
(Price and Laughon, 1993)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000002329
(GO Reference Genome Project, 2011-)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:P09440
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (Q04448)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
methylenetetrahydrofolate dehydrogenase (NAD+) activity
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10- methenyltetrahydrofolate + NADH (1.5.1.15)
RHEA 22892: methenyltetrahydrofolate cyclohydrolase activity
(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+) (3.5.4.9)
RHEA 23700: methylenetetrahydrofolate dehydrogenase (NADP+) activity
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10- methenyltetrahydrofolate + NADPH (1.5.1.5)
RHEA 22812:
Summaries
Gene Group (FlyBase)
CH-NH OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR -
CH-NH oxidoreductases with NAD or NADP as acceptor, include dehydrogenases that oxidize a CH-NH with the reduction of NAD or NADP.
UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF CYCLIC AMIDINES -
This group comprises carbon-nitrogen hydrolases of cyclic amidines that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
May play a role in spermatogenesis.
(UniProt, Q04448)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Nmdmc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q04448)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Nmdmc-RA
FBtr0081997
NM_057582
1156
303
Nmdmc-RB
FBtr0081996
NM_057581
1257
309
Nmdmc-RC
FBtr0336761
NM_001275469
1233
303
Additional Transcript Data and Comments
Reported size (kB)

1.25 (northern blot)

(Price and Laughon, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Nmdmc-PA
FBpp0081477
32.8
303
7.27
A0A0B4KFE5
NP_476930
AAF54332
Nmdmc-PB
FBpp0081476
33.6
309
7.60
Q04448
NP_476929
AAN13408
Nmdmc-PC
FBpp0307737
32.8
303
7.27
A0A0B4KFE5
NP_001262398
AGB95780
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

303 aa isoforms: Nmdmc-PA, Nmdmc-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

309, 303 (aa)

(Hedengren et al., 1999)

357 (aa); 39 (kD predicted)

(Price and Laughon, 1993)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer.

(UniProt, Q04448)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nmdmc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
rectum primordium

Comment: reported as rectum specific anlage

(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
embryonic rectum
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Price and Laughon, 1993)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Mitochondrial localization is predicted based on the presence of a mitochondrial targeting sequence, and on amino acid identity with mitochondrial proteins from other species.

(Price and Laughon, 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nmdmc in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nmdmc
Transgenic constructs containing regulatory region of Nmdmc
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6258
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority live, with Scer\GAL4da.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage, with Scer\GAL4da.PU
abnormal stress response | adult stage | RU486 conditional, with Scer\GAL4da.Switch.PT
abnormal stress response | adult stage | RU486 conditional, with Scer\GAL4Switch1.106
decreased rate of flight behavior, with Scer\GAL4Act88F.PB
long lived, with Scer\GAL4da.PU
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
long lived | RU486 conditional, with Scer\GAL4Switch1.106
short lived, with Scer\GAL4da.PU
short lived | RU486 conditional, with Scer\GAL4da.Switch.PT
short lived | RU486 conditional, with Scer\GAL4Switch1.106
visible | adult stage, with Scer\GAL4da.PU
Phenotype manifest in
Allele
indirect flight muscle cell | adult stage, with Scer\GAL4da.PU
larval brain | larval stage, with Scer\GAL4elav.PU
mitochondrion | adult stage, with Scer\GAL4da.PU
mitochondrion | larval stage, with Scer\GAL4elav.PU
wing, with Scer\GAL4da.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\MTHFD2
13 of 14
Yes
Yes
Hsap\MTHFD2L
12 of 14
No
Yes
Hsap\MTHFD1
2 of 14
No
No
Hsap\MTHFD1L
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Mthfd2l
13 of 14
Yes
Yes
Rnor\Mthfd2
13 of 14
Yes
Yes
Rnor\LOC680432
2 of 14
No
No
Rnor\Mthfd1l
2 of 14
No
No
Rnor\Mthfd1
2 of 14
No
No
Mus musculus (laboratory mouse) (4)
Mmus\Mthfd2
13 of 14
Yes
Yes
Mmus\Mthfd2l
12 of 14
No
Yes
Mmus\Mthfd1l
2 of 14
No
No
Mmus\Mthfd1
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\mthfd2l
10 of 13
Yes
Yes
Xtro\mthfd2
7 of 13
No
Yes
Xtro\man2b2
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\mthfd2l
13 of 14
Yes
Yes
Drer\mthfd2
12 of 14
No
Yes
Drer\mthfd1a
2 of 14
No
No
Drer\mthfd1b
2 of 14
No
No
Drer\mthfd1l
2 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\dao-3
8 of 14
Yes
Yes
Cele\K07E3.4
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP004677
11 of 12
Yes
Yes
Agam\AgaP_AGAP002830
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT3G12290
11 of 13
Yes
Yes
Atha\EMB3127
11 of 13
Yes
Yes
Atha\AT2G38660
10 of 13
No
Yes
Atha\AT4G00600
10 of 13
No
Yes
Atha\THFS
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\MIS1
4 of 13
Yes
No
Scer\MTD1
3 of 13
No
Yes
Scer\ADE3
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPBC1711.04
3 of 12
Yes
Yes
Spom\ade9
2 of 12
No
No
Spom\SPBC839.16
2 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\folD
11 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Nmdmc. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
pug
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
    13 of 14
    604887
        MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
        12 of 14
        614047
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Nmdmc - Smn
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            park
            enhanceable
            Nmdmc
            (Celardo et al., 2017)
            Pink1
            suppressible
            Nmdmc
            (Celardo et al., 2017)
            Pink1
            enhanceable
            Nmdmc
            (Celardo et al., 2017)
            External Data
            Subunit Structure (UniProtKB)
            Homodimer.
            (UniProt, Q04448 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-48
            Cytogenetic map
            85C3-85C3
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            85C3-85C3
            Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            85C-85C
            (determined by in situ hybridisation)
            (Price and Laughon, 1993)
            Experimentally Determined Recombination Data
            Location

            3-48

            (FlyBase, 2016)

            3-45.8

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (12)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (14)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

                (McDonald and Rosbash, 2001)

                Nmdmc enzyme activity in the S3 cell line has been analysed.

                (Tremblay et al., 1995)

                Identification: Part of molecular analysis of the neur genomic region.

                (Price and Laughon, 1993)

                Nmdmc has been cloned and sequenced.

                (Price and Laughon, 1993)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Nmdmc CG18466

                (Misra, 2000.4.14)
                Additional comments

                pug is a different gene from Nmdmc; pug (at 86C) appears to encode the cytoplasmic form of methylenetetrahydrofolate dehydrogenase, Nmdmc (at 85C) appears to encode the mitochondrial form of methylenetetrahydrofolate dehydrogenase.

                (Rong and Golic, 1998)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (11)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 66 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                References (86)