Flies expressing Aps^KK108331 under the control of Scer\GAL4^elav-C155 are more susceptible to starvation and total lipid levels are elevated compared with controls. Under well-fed conditions the flies eat significantly more than control flies and total lipid levels are slightly, but not significantly, elevated. Circulating glucose and trehalose levels are reduced compared with controls both with and without starvation. There is no difference in weight between the Aps^KK108331-expressing flies and controls.

When Aps^KK108331 is expressed specifically in the insulin producing cells under the control of Scer\GAL4^Ilp2.PR lipid levels in well-fed males are not significantly different from controls. However, lipid levels during starvation are increased. There is no change in circulating trehalose levels in well-fed flies but levels are significantly lower following starvation. Trehalose levels are reduced compared to controls in well-fed and starved flies. Body trehalose levels are higher prior to starvation, but are lower than controls during starvation. Circulating glucose levels are also significantly reduced during starvation but, in contrast to control flies, starved flies expressing Aps^KK108331 do not exhibit an increase in circulating glucose levels when glucose is reintroduced after starvation. Glycogen levels are also reduced upon starvation but unchanged from controls in well-fed flies. There is no difference in weight between the Aps^KK108331-expressing flies and controls.