FB2026_02 , released June 18, 2026
Allele: Dmel\lola46.38
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General Information
Symbol
Dmel\lola46.38
Species
D. melanogaster
Name
FlyBase ID
FBal0260765
Feature type
allele
Associated gene
Dmel\lola
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Weyers et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: H844L.

(Silva et al., 2016)

Mutation in the second zinc finger of lola isoform T (PR/PG).

(Silva et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,483,085..10,483,085 [-]
Nucleotide change:

A10483085T

Amino acid change:

H389L | pre-lola-G-PC; H389L | pre-lola-G-PD; H844L | lola-PG; H844L | lola-PR

Reported amino acid change:

H844L

Comment:

Reported relative to isoform K, which corresponds to FlyBase lola-PG and lola-PR. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Silva et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lola46.38/lola22.05 and lola46.38/lolae76 transheterozygous embryos, but not lola46.38 heterozygotes, display a significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.

      lola46.38/lola22.05 transheterozygous embryos also display a significant increase in the number of extragonadal primordial germ cells, but no obvious defects in the development of the visceral mesoderm, as compared to controls.

      (Silva et al., 2016)

      lola22.05/lola46.38 embryos have gonads with at least one somatic gonadal precursor (SGP) cluster that does not fuse with other SGPs. Somatic gonadal precursor specification appears normal. Visceral mesoderm appears normal.

      (Weyers et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      lola46.38/lola22.05 has gonad | embryonic stage phenotype, enhanceable by rib55.25/rib[+]

      (Silva et al., 2016)

      lola46.38/lola22.05 has gonadal sheath proper primordium phenotype, enhanceable by rib55.25/rib[+]

      (Silva et al., 2016)

      lola46.38/lola22.05 has germline cell | embryonic stage phenotype, enhanceable by rib55.25/rib[+]

      (Silva et al., 2016)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      lola46.38/+, rib55.25/+ double heterozygous embryos display a very significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.

      The defects exhibited by lola46.38/lola22.05 transheterozygous embryos to fuse together and compact primordial germ cells and somatic gonadal precursor cells are significantly enhanced by heterozygosity for rib55.25.

      (Silva et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lola46.38
      (Silva et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)