FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bazGD21
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General Information
Symbol
Dmel\bazGD21
Species
D. melanogaster
Name
FlyBase ID
FBal0260791
Feature type
allele
Associated gene
Dmel\baz
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Contains a 4bp deletion of nucleotides 793-796 in the open reading frame, causing a frameshift predicted to truncate the protein after 264 of 1464 amino acids, removing the PDZ domains, aPKC-binding region and C-terminal domain.

    (Simões et al., 2010)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    X:17,189,664..17,189,667 [+]
    Comment:

    A 4bp deletion of nucleotides 793-796 of the open reading frame, causing a frameshift predicted to truncate the protein after 264 of 1464 amino acids. Position of deletion on reference sequence inferred by FlyBase curator.

    (Simões et al., 2010)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        bazGD21 homozygotes are zygotic lethal. This is rescued by the presence of Dp(1;Y)W73 (which contains the baz open reading frame).

        Germband elongation is strongly reduced in bazGD21 mutants. Mutant cells engage in fewer rearrangements and display a reduction in both neighbor exchange and rosette formation. Cell movements that do occur in bazGD21 mutants show a moderate loss of directionality. Some cells begin to apically constrict in late stage 7, leading to the formation of ectopic grooves in stage 8. These defects are not due to apoptosis.

        (Simões et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        bazGD21
        (Simões et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)