FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pi4KIIIαGS27
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General Information
Symbol
Dmel\Pi4KIIIαGS27
Species
D. melanogaster
Name
FlyBase ID
FBal0260806
Feature type
allele
Associated gene
Dmel\Pi4KIIIα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q1778term.

    (Yan et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:2,631,898..2,631,898 [+]
    Nucleotide change:

    C2631898T

    Amino acid change:

    Q1734term | PI4KIIIalpha-PC; Q1754term | PI4KIIIalpha-PD

    Reported amino acid change:

    Q1778term

    Comment:

    The reported amino acid position for the mutation was based on a predicted protein length of 2178 amino acids. The current Pi4KIIIalpha annotation is shorter by 44 amino acids due to the use of a different splice donor site in the first intron. The mapped amino acid position has been shifted accordingly. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Yan et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Alzheimer's disease 1
        modeled by Hsap\APPArctic.UAS.Tag:SS(nec)
        (Zhang et al., 2017)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In mosaic egg chambers containing mutant posterior follicle cells, the oocyte nucleus remains at the posterior end of the oocyte in 47.7% of late egg chambers. The mutant posterior follicle cells often lose their monolayered epithelial structure after stage 6 and have smaller nuclei than surrounding cells. Mutant clones on the lateral side of the egg chamber show normal epithelial structure.

        (Yan et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        PI4KIIIαGS27
        (Khoury and Bilder, 2020, Zhang et al., 2017, Devergne et al., 2014, Yan et al., 2011)
        Pi4KIIIαGS27
        pi4kGS27
        (Zhang et al., 2022)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)