FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cul4JJ11
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General Information
Symbol
Dmel\Cul4JJ11
Species
D. melanogaster
Name
FlyBase ID
FBal0261055
Feature type
allele
Associated gene
Dmel\Cul4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lin et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: W199term.

(Lin et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,105,126..8,105,126 [-]
Nucleotide change:

G8105126A

Amino acid change:

W199term | Cul4-PA; W199term | Cul4-PB

Reported amino acid change:

W199term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

(Lin et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals containing eye-specific clones of Cul4JJ11 (in combination with Scer\FLP1ey.PN) exhibit smaller eye discs and smaller adult eyes while they exhibit an increase in the size of head capsule.

      Third instar larvae containing eye-disc-specific clones of Cul4JJ11 (in combination with Scer\FLP1ey.PN) exhibit increased occurrence of cell division in the eye disc anterior to the morphogenetic furrow (MF).

      Third instar larvae containing eye-disc-specific clones of Cul4JJ11 (in combination with Scer\FLP1ey.PN) exhibit a defective pattern for R8 positive cells and a disruption in the progression of MF.

      (Tare et al., 2020)

      Cul4JJ11 homozygotes exhibit signs of quiescence in the larval brain: neuroblasts show a significant decrease in cell divisions (both DNA replication/EdU staining and Mitosis/phospho-H3); are significantly decreased in number; and frequently show a primary cellular process, whereas control neuroblasts show a typically rounded morphology. Likewise, Cul4JJ11 neuroblast clones in the larval brain also show a significant decrease in cell divisions (DNA replication/EdU staining).

      (Ly et al., 2019)

      Homozygous Cul-4JJ11 mutants are arrested in the second-instar larval stage.

      (Lin et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Cul-4JJ11
      Cul4JJ11
      (Lin et al., 2009)
      cul-4JJ11
      (Tare et al., 2020)
      cul4JJ11
      (Ly et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)