FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hr3W284X
Open Close
General Information
Symbol
Dmel\Hr3W284X
Species
D. melanogaster
Name
FlyBase ID
FBal0261087
Feature type
allele
Associated gene
Dmel\Hr3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Montagne et al., 2010)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,208,803..10,208,803 [-]
Nucleotide change:

G10208803A

Amino acid change:

W284term | Hr3-PA; W491term | Hr3-PC; W253term | Hr3-PD; W284term | Hr3-PF; W284term | Hr3-PH; W668term | Hr3-PI

Reported amino acid change:

W284term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Montagne et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544 fails to generate a bent-down wing phenotype in a Hr46W284X background.

      Eyes containing Hr46W284X cell clones exhibit a significant reduction in eye size.

      Hr46K243X mutant bristle clones on the scutellum are significantly reduced in size. The orientation of these bristles is also affected, as compared to the surrounding bristles. Misorientation is also observed for the ommatidia-associated bristles in homozygous Hr46W284X clones.

      Compared to control eyes, homozygous Hr46W284X mutant eyes exhibit a significant reduction in surface area. The reduction in ommatidia area is not as strong as for the surface of the entire eye, indicating that the number of ommatidia is also affected.

      (Montagne et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DHR3W284X
      (Montagne et al., 2010)
      Hr3W284X
      Hr46W284X
      Name Synonyms
      Secondary FlyBase IDs
        References (1)