FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brv2W205STOP
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General Information
Symbol
Dmel\brv2W205STOP
Species
D. melanogaster
Name
FlyBase ID
FBal0262483
Feature type
allele
Associated gene
Dmel\brv2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Gallio et al., 2011)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W205term.

    (Gallio et al., 2011)

    Mutation truncates the protein before the ion transporter domain.

    (Gallio et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:17,343,915..17,343,915 [-]
    Nucleotide change:

    G17343915A

    Reported nucleotide change:

    G?A

    Amino acid change:

    W205term | brv2-PA; W183term | brv2-PB

    Reported amino acid change:

    W205term

    Comment:

    TGG to TAG nonsense mutation in codon W205, 754 bases from the start codon.

    (Gallio et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        brv2W205STOP homozygotes and brv2W205STOP/Df(3L)Exel6131 animals show a dramatic deficit in their aversion to cold temperatures compared to wild type flies.

        Cold-evoked calcium transients of brv1-expressing cells are severely decreased in brv2W205STOP animals.

        (Gallio et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        brv2W205STOP is rescued by brv2+t4

        (Gallio et al., 2011)
        Comments

        Introduction of brv2+t4 into the brv2W205STOP background completely restores normal temperature preference to the mutant flies.

        (Gallio et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        brv2<up>W205 > STOP</up>
        (Gallio et al., 2011)
        brv2W205STOP
        brv2w205stop
        (Ni et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)