FlyBase Allele Report: Dmel\Desat1[GL00428]

General Information

Symbol

Dmel\Desat1^GL00428

Species

D. melanogaster

Name

FlyBase ID

FBal0262894

Feature type

allele

Associated gene

Dmel\Desat1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00428}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00428}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00428

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell size | third instar larval stage, with Scer\GAL4^DcG

(Ugrankar et al., 2019)

abnormal size | third instar larval stage, with Scer\GAL4^DcG

(Ugrankar et al., 2019)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^DcG

(Ugrankar et al., 2019)

fat cell | third instar larval stage, with Scer\GAL4^DcG

(Ugrankar et al., 2019)

lipid droplet | third instar larval stage, with Scer\GAL4^DcG

(Ugrankar et al., 2019)

Detailed Description

Statement

Reference

Expressing snz^UAS.FL under the control of Scer\GAL4^DcG leads to third instar larval exhibiting reduced fat body tissue, with individual fat cells appearing deflated and poorly connected to one another, as compared to controls; their peripheral lipid droplets are irregular in size.

(Ugrankar et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Desat1^GL00428, Scer\GAL4^DcG has abnormal size | third instar larval stage phenotype, non-suppressible by snz^UAS.FL, Scer\GAL4^DcG

(Ugrankar et al., 2019)

Desat1^GL00428, Scer\GAL4^DcG has abnormal cell size | third instar larval stage phenotype, non-suppressible by snz^UAS.FL, Scer\GAL4^DcG