FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\expHMS01445
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General Information
Symbol
Dmel\expHMS01445
Species
D. melanogaster
Name
FlyBase ID
FBal0263353
Feature type
allele
Associated gene
Dmel\exp
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01445}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS01445}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01445
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4btl.PU-mediated expression of expHMS01445 produces no detectable defects in the pattern of migration, organisation, or diversification of tracheal cells. However, a clear defect in chitin deposition is detected - luminal chitin accumulation is prevented in dorsal and ventral branches, remaining only in the dorsal trunk and part of the transverse connective. Only the branches that accumulate chitin fill with gas.

      Scer\GAL4tub.PU- or Scer\GAL469B-mediated expression of expHMS01445 results in inflated and shorter embryos that show defects in the head skeleton. 20% of embryos show defective mouth inversion or rotation.

      (Moussian et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4btl.PU-mediated expression of expHMS01445 in a Df(2R)BSC329/Df(2R)BSC879 background (that removes reb) results in embryos with a normal branching pattern but devoid of the chitin filament. Branches do not fill with air a the end of embryogenesis and embryos die.

      (Moussian et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG13188HMS01445
      expHMS01445
      Name Synonyms
      Secondary FlyBase IDs
        References (2)