FlyBase Allele Report: Dmel\Cln3[HMS01476]

General Information

Symbol

Dmel\Cln3^HMS01476

Species

D. melanogaster

Name

FlyBase ID

FBal0263384

Feature type

allele

Associated gene

Dmel\Cln3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01476}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01476}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01476

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Wong et al., 2015)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Wong et al., 2015)

NMJ bouton | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Wong et al., 2015)

Detailed Description

Statement

Reference

Expression of cln3^HMS01476 RNAi under the control of the Scer\GAL4^VGlut-OK371 in third instar larvae results in a decrease in the number of neuromuscular junction boutons compared to controls. This phenotype is partially rescued if the larvae are raised on a protein-rich diet supplemented with the ALK inhibitor CH5424802.

(Wong et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cln3^HMS01476/Scer\GAL4^VGlut1-OK371 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of hiw^ND8

(Wong et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cln3^HMS01476/Scer\GAL4^VGlut1-OK371 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of hiw^ND8

(Wong et al., 2015)

Cln3^HMS01476/Scer\GAL4^VGlut1-OK371 is a suppressor of NMJ bouton | third instar larval stage phenotype of hiw^ND8

(Wong et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of cln3^HMS01476 RNAi under the control of the Scer\GAL4^VGlut-OK371 in the hiw^ND8 mutant background lowers the increased number of neuromuscular junction boutons characteristic for the hiw^ND8 mutant third instar larvae.

(Wong et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35734

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01476}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cln3^HMS01476

cln3^HMS01476

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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