FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zydGD3723
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General Information
Symbol
Dmel\zydGD3723
Species
D. melanogaster
Name
FlyBase ID
FBal0263592
Feature type
allele
Associated gene
Dmel\zyd
Associated Insertion(s)
Carried in Construct
P{GD3723}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Mummery-Widmer et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Mummery-Widmer et al., 2009)
Mutagen
in vitro construct
(Mummery-Widmer et al., 2009)
Progenitor genotype
Carried in construct
P{GD3723}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Mummery-Widmer et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD3723
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  epilepsy
      CEA
      (Weiss et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of zydGD3723 under the control of Scer\GAL4elav-C155 does not affect central pattern generator activity in mutant larvae at 38[o]C.

      Expression of zydGD3723 under the control of Scer\GAL4repo at 38[o]C results in rapid, seizure-like discharges in the larval muscle and semi-lethality in adults.

      Expression of zydGD3723 under the control of either Scer\GAL4Akap200-NP2222, Scer\GAL4NP577 or Scer\GAL4nrv2.PS at 38[o]C results in seizures.

      Expression of zydGD3723 under the control of Scer\GAL4wun-NP1243 at 38[o]C results in intermittent seizures.

      Expression of zydGD3723 under the control of either Scer\GAL4alrm.PD, Scer\GAL4Eaat1.PR, Scer\GAL4Mz709, Scer\GAL4NP6520, Scer\GAL4Bsg-NP6293, Scer\GAL4spin-NP2276 or Scer\GAL4gcm-rA87.P at 38[o]C does not results in seizures.

      (Melom and Littleton, 2013)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG2893GD3723
      zydGD3723
      Name Synonyms
      Secondary FlyBase IDs
        References (7)