FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\thoc51
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General Information
Symbol
Dmel\thoc51
Species
D. melanogaster
Name
FlyBase ID
FBal0263654
Feature type
allele
Associated gene
Dmel\thoc5
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    An in frame deletion of 255 bp in exon 5 of thoc5.

    (Moon et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        thoc51/thoc5e00906 and homozygous thoc51 mutant testes contain primary spermatocytes but lack post-meiotic cells. thoc51 mutant spermatocytes show abnormally strong condensation of three major bivalent chromosomes and the phase-dark structure of the nucleolus is severely disorganised.

        thoc51/thoc5e00906 trans-heterozygotes are male sterile.

        (Moon et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Expression of Mmus\Thoc5Scer\UAS.cMa under the control of Scer\GAL4da.G32 partially rescues the mutant testis phenotypes. Nucleolar structure is restored to normal. Chromosome condensation is much similar to wild-type, although chromosome shape appear somewhat abnormal. Elongating spermatid flagella are observed.

        (Moon et al., 2011)
        Complementation and Rescue Data
        Rescued by

        thoc51 is rescued by thoc5+t7.9

        (Moon et al., 2011)
        Comments

        thoc5+t7.9 rescues the meiotic arrest phenotype of thoc51.

        (Moon et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        garm1
        (Moon et al., 2011)
        thoc51
        (Zhang et al., 2021, Hur et al., 2016, Moon et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)