FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Keap1RNAi.UAS
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General Information
Symbol
Dmel\Keap1RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0263739
Feature type
allele
Associated gene
Dmel\Keap1
Associated Insertion(s)
Carried in Construct
P{UAS-Keap1.RNAi}
Also Known As
UAS-Keap1RNAi
Key Links
Transgenic product class
RNAi_reagent
(Sykiotis and Bohmann, 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Sykiotis and Bohmann, 2008)
Mutagen
in vitro construct
(Sykiotis and Bohmann, 2008)
Progenitor genotype
Carried in construct
P{UAS-Keap1.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat targeting Keap1 for RNAi mediated knockdown.

(Sykiotis and Bohmann, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Keap1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cTa
      (Barone et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Keap1dsRNA.Scer\UAS under the control of Scer\GAL4phm.PO results in delayed pupation compared to controls.

      Pupae expressing Keap1dsRNA.Scer\UAS under the control of Scer\GAL4phm.PO are larger than control larvae.

      (Deng and Kerppola, 2013)

      Expression of Keap1dsRNA.Scer\UAS under the control of Scer\GAL4ple.PF has no effect on locomotor performance.

      (Barone et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Flies co-expressing Hsap\SNCAScer\UAS.cTa and Keap1dsRNA.Scer\UAS under the control of Scer\GAL4ple.PF display locomotor activity similar to that of wild-type flies, indicating suppression of the age-dependent negative geotaxis response found in Hsap\SNCAScer\UAS.cTa-expressing flies.

      (Barone et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Keap1RNAi.UAS
      Keap1dsRNA.Scer\UAS
      Keap1dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (10)