FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CanB2KO
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General Information
Symbol
Dmel\CanB2KO
Species
D. melanogaster
Name
FlyBase ID
FBal0263894
Feature type
allele
Associated gene
Dmel\CanB2
Associated Insertion(s)
TI{TI}CanB2KO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Nakai et al., 2011)
Mutagen
ends-out gene targeting
(Nakai et al., 2011)
I-SceI
(Nakai et al., 2011)
FLPase
(Nakai et al., 2011)
Progenitor genotype
Associated Insertion(s)
TI{TI}CanB2KO
Cytology
Description

Precise replacement of the CanB2 coding sequence by a loxP cassette containing a w+* marker. An attP site is present downstream of the 3' loxP site to allow future integration of constructs into the knock-out site.

(Nakai et al., 2011)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  epilepsy
      modeled by zyd1
      (Weiss et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CanB2KO mutants exhibit a 10% decrease in the total sleep level, both in LD and DD conditions, but do no exhibit a significant change in total activity, compared to wild-type.

      (Nakai et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CanB2KO
      (Weiss et al., 2019, Nakai et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)