FB2022_02, released March 29, 2022

Allele: Dmel\perM2M1

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General Information
Symbol
Dmel\perM2M1
Species
D. melanogaster
Name
FlyBase ID
FBal0264021
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{dmpi8UP}
Also Known As
P{dmper/M2M1}
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - site directed mutagenesis
(Low et al., 2008)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      per8:8
      (Low et al., 2008)
      Carried in construct
      P{dmpi8UP}
      Cytology
      Nature of the lesion
      Statement
      Reference

      Both the 5' and 3' splice sites of the per 3' terminal intron have been mutated to the consensus sequence to increase splicing efficiency.

      (Low et al., 2008)
      Allele components
      Product class / Tool use(s)
      Encoded product / tool
      per
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transgenic perM2M1 flies in a per01 mutant genetic background exhibit sleep patterns that are different to those previously described for wild-type strains at 18[o]C and 25[o]. While daytime sleep is reduced compared with wild-type, nighttime sleep appears normal. The transgenic mutant flies also sleep less during the nighttime in the presence of light at 18[o]C and 25[o]. However, at the elevated temperature of 29[o]C, daytime sleep is similar for transgenic mutant and wild-type flies, and high temperature strongly inhibits daytime activity in both perM2M1 , per01 transgenic mutants and wild-type.

      (Cao and Edery, 2015)

      per01 flies rescued with perM2M1 generally show earlier onsets of evening activity and shorter, less robust, midday siestas compared to per01 flies rescued with per8:8.

      (Low et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      perM2M1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)