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General Information
Symbol
Dmel\perM2M1
Species
D. melanogaster
Name
FlyBase ID
FBal0264021
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P{dmper/M2M1}
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Both the 5' and 3' splice sites of the per 3' terminal intron have been mutated to the consensus sequence to increase splicing efficiency.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Transgenic perM2M1 flies in a per01 mutant genetic background exhibit sleep patterns that are different to those previously described for wild-type strains at 18[o]C and 25[o]. While daytime sleep is reduced compared with wild-type, nighttime sleep appears normal. The transgenic mutant flies also sleep less during the nighttime in the presence of light at 18[o]C and 25[o]. However, at the elevated temperature of 29[o]C, daytime sleep is similar for transgenic mutant and wild-type flies, and high temperature strongly inhibits daytime activity in both perM2M1 , per01 transgenic mutants and wild-type.

per01 flies rescued with perM2M1 generally show earlier onsets of evening activity and shorter, less robust, midday siestas compared to per01 flies rescued with per8:8.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
perM2M1
Name Synonyms
Secondary FlyBase IDs
    References (3)