FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grh2E.UAS
Open Close
General Information
Symbol
Dmel\grh2E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264178
Feature type
allele
Associated gene
Dmel\grh
Associated Insertion(s)
Carried in Construct
P{UAS-grh.2E}
Key Links
Transgenic product class
missense_variant
(Kim and McGinnis, 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kim and McGinnis, 2011)
Mutagen
in vitro construct
(Kim and McGinnis, 2011)
Progenitor genotype
grhUAS.cKa
(Kim and McGinnis, 2011)
Carried in construct
P{UAS-grh.2E}
Cytology
Description

Two amino acid replacements (S88E and S91E) have been introduced into grhUAS.cKa.

(Kim and McGinnis, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
grh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4e22c/grh2E.UAS partially rescues grhIM

      (Kim and McGinnis, 2011)
      Comments

      Expression of grh2E.Scer\UAS in the epidermis under the control of Scer\GAL4e22c partially rescues the cuticle and head skeleton defects seen in grhIM embryos.

      Expression of grh2E.Scer\UAS in the epidermis under the control of Scer\GAL4e22c rescues the defects in epidermal barrier integrity seen in stage 17 grhIM homozygous embryos. Epidermal barrier regeneration following wounding is also rescued.

      (Kim and McGinnis, 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      grh2E.Scer\UAS
      grh2E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)