FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\APP3HR.Aβ42.UAS
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General Information
Symbol
Hsap\APP3HR.Aβ42.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0264200
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
M{UAS-Aβ42.3HR}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hua et al., 2011)
Progenitor genotype
Carried in construct
M{UAS-Aβ42.3HR}
Cytology
Description

5 copies of UAS regulatory sequences drive expression of a mutant Aβ1-42 peptide of Hsap\APP with three histidines (His 6, 13 and 14 of the metal binding site) changed into arginines.

(Hua et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\APP3HR.attB.Aβ42.Scer\UAS under the control of Scer\GAL4GMR.PF causes only mild eye degeneration, which can not be exacerbated by feeding the flies extra zinc.

      (Hua et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\APP3HR.Aβ42.Scer\UAS
      Hsap\APP3HR.Aβ42.UAS
      Hsap\APP3HR.attB.Aβ42.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)